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"And the stars are projectors, yeah, projecting our lives down to this planet Earth." - Modest Mouse


4.28.2004

DNA Computing 

AP News reports on the recent development of a potentially-injectible molecular-scale biocomputer composed of DNA and enzymes, further blurring the lines between science fiction and reality.
The molecular-scale device, which is essentially a liquid mixture of synthetic DNA and enzymes, is designed to sniff out chemical signs of disease and pump out drugs in response.

Molecular computers have only been around for a decade. Instead of micro chips and processors, they harness the software-like ability of DNA strands to store information. Enzymes "read" chemical sequences on the DNA in a way that allows the computer to perform calculations.

Experts say such computers could become extremely powerful, given DNA's potential to store huge amounts of information. The computing power of 1 trillion compact discs could be stored in less than an ounce of dried DNA.

"It's really an ingenious concept," Reif said of Shapiro's computer. "This could have a major significance in the medical world, if only they could get it in the cell."

In the future, a doctor might inject trillions of the devices into a patient. The computer is designed to detect cancer by monitoring concentrations of certain molecules. If cancer is detected, the computer releases other molecules that interfere with a cancer cell's activities and cause it to self-destruct.

Unlike many of its predecessors, the computer is autonomous -- it doesn't need supervision or added chemicals to make it work.

Shapiro, who received a U.S. patent for a previous version in 2001, said the new computer worked fine detecting chemical markers of lung and prostate cancer in lab experiments using a pristine water solution.

But it could get confused if it were put in a medium teeming with other molecules, Shapiro said. "There could be many reactions with many other molecules that may be detrimental to either the computer or to the cell in which it operates."

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